The great advance in knowledge of hormones, especially the sex hormones," made in the past ten years has led to renewed interest in the problem of the relation of the endocrine glands to personality and to mental disorders. In the past it had been claimed, on the one hand, that there is a close etiologic relationship between the endocrine glands and mental disorders and, on the other, that no such relationship exists. Recent reports in the literature on the use of androgens and estrogens in the treatment of endocrine and psychiatric disorders and quantitative studies on the excretion of these substances in the urine by patients presenting various psychiatric and endocrine syndromes have led us to make an investigation of the problem in eunuchoidism.
Eunuchoidism is a syndrome characterized by hypoplasia of the testes and accessory genitalia, deficiency in secondary sex characters, delay in fusion of the epiphyses of the