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November 1938

LATE DAMAGE FROM ROENTGEN IRRADIATION OF THE HUMAN BRAIN

Arch NeurPsych. 1938;40(5):928-936. doi:10.1001/archneurpsyc.1938.02270110082006
Abstract

The heads of 3 deteriorated young patients with schizophrenia were irradiated for the purpose of investigating the effect of roentgen rays on the permeability of the barrier between the blood and the cerebrospinal fluid.1 Exposure was made through six portals, with a 180 to 270 per cent erythema skin dose for each portal, calculated to give an even distribution through the brain of about 400 per cent erythema skin dose.2 Each course was completed in three days. There was some indication in 2 cases that the permeability was increased at the end of four and one-half and six and one-half weeks, respectively, after irradiation, which seems to parallel the histologic changes in the Frühreaction of irradiated dogs, as described by one of us (W. S.).3

There remains to be determined whether the dose and timing of the roentgen exposures were safe from the standpoint of late damage

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