Modern interest in fever therapy began with the monumental contribution of Wagner von Jauregg1 in 1917, proving the curative value of malarial therapy in cases of dementia paralytica. For the first fifteen years extensive experimentation was carried on by means of biologic, chemical and infectious induction of body fever by so-called nonspecific foreign protein shock. More recently extensive investigations with various physical methods of artificial fever production have been carried out. After twenty-five years of clinical application of various methods, one can state that artificial fever therapy has a permanent place in medical therapeutics. However, the significance of body fever and its relation to the course of disease is as yet not fully understood.
After ten years of experience with malarial fever in treatment of paralytic dementia, in spite of the excellent results often reported, my personal results have been far from satisfactory. The inherent dangers of engrafting one