That the Argyll Robertson pupil may occur in nonsyphilitic disease of the central nervous system is not well appreciated in clinical medicine. Ordinarily, one associates such a pupillary reaction with tabes or dementia paralytica. However, it is important to bear in mind other conditions in which this pupillary reaction may occur, infrequent though it may be. Cases have been reported in which an Argyll Robertson pupil has been observed in association with multiple sclerosis;1 meningitis;2 wood alcohol poisoning;3 arteriosclerosis;4 encephalitis;5 diabetes,6 and tumors of the pituitary gland,7 pons8 and colliculi.9
Argyll Robertson10 described the characteristic pupil as miotic, not responding to light but reacting normally to stimuli of accommodation and convergence, and of irregular outline, with little or no response to mydriatic drugs or psychogenic stimuli.
Moore11 stated that in cases of nonsyphilitic conditions the pupil has special characteristics:
Herman M. ARGYLL ROBERTSON PUPILS IN ALCOHOLISM. Arch NeurPsych. 1939;41(4):800–803. doi:10.1001/archneurpsyc.1939.02270160156013
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