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April 1939

Beitrag zur Kenntnis sklerosierender Entmarkungsprozesse im Gehirn, mit besonderer Berücksichtigung der diffusen Sklerose.

Arch NeurPsych. 1939;41(4):869. doi:10.1001/archneurpsyc.1939.02270160225024

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The authors define diffuse sclerosis as a primary, progressive process of demyelination and sclerosis, which takes place in the white matter of the two hemispheres equally or to different degrees, which ordinarily spares the cortex and arcuate fibers and in which the details of the reaction, especially in the glia, display marked variations. They recognize the following forms: (1) that with glioblastomatous reaction; (2) that with inflammatory reaction (Schilder); (3) the nonfamilial, sporadic, degenerative types (a) with fatty products, (b) with metachromatic-basophilic products and (c) with persistent islands and stripes of myelin; (4) the heredodegenerative, familial types, including (a) the acute infantile (Krabbe), (b) the subacute juvenile (Scholtz), (c) the adult (Ferraro) and (d) the chronic (Pelizaeus-Merzbacher), and (5) leukoencephalopathia concentrica (Baló).

After discussing some other classifications and miscellaneous cases, they conclude: "A division of types which suits every one cannot now be given, in view of the incomplete knowledge