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May 1939


Author Affiliations


From the Neurological Unit, the Boston City Hospital, and the Department of Neurology, Harvard Medical School.

Arch NeurPsych. 1939;41(5):913-920. doi:10.1001/archneurpsyc.1939.02270170051002

Almost every authority since Valentiner1 (1856) who has written about multiple sclerosis has mentioned the occurrence of remissions. Few special studies have been devoted to their occurrence, however. Von Hoesslin2 made a survey of the histories in 516 cases of multiple sclerosis. He found that remissions were recorded in 92, or 17 per cent. The duration of remissions was: from one-fourth to two years, in 17 cases; from three to four years, in 10 cases; from five to six years, in 10 cases; from seven to ten years, in 16 cases, and from eleven to twelve years, in 3 cases. In 11 cases the remissions lasted from fourteen to twenty-five years, and in 1 case, forty-five years. Von Hoesslin made no particular attempt to investigate the improvement in individual symptoms.

MATERIAL AND METHODS  The present study is based on the records of 133 patients. Of these, 95 were

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