In a previous report from the Emma Pendleton Bradley Home1 it has been shown that medication with benzedrine sulfate had a beneficial effect on certain children with severe behavior problems. It has also been reported2 that over half a group of 71 behavior problem children from this hospital showed distinctly abnormal electroencephalograms. The question arises as to a possible relationship between the beneficial effects of benzedrine sulfate and the functional abnormalities of the brain as revealed by the electroencephalogram. Since the type of brain potentials observed and the personality deviations in these patients often suggested an epileptiform disorder of the brain, the effect of phenobarbital therapy alone and in combination with benzedrine was also studied.
Twelve behavior problem children, 2 girls and 10 boys, between 7 and 10 years of age were selected for intensive study. These children were all admitted to the hospital because of
CUTTS KK, JASPER HH. EFFECT OF BENZEDRINE SULFATE AND PHENOBARBITAL ON BEHAVIOR PROBLEM CHILDREN WITH ABNORMAL ELECTROENCEPHALOGRAMS. Arch NeurPsych. 1939;41(6):1138–1145. doi:10.1001/archneurpsyc.1939.02270180066006
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