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July 1939

Essai de traitement de la migraine et de l'epilepsie les solutions, hypertoniques: Etude clinique et experimentale.

Arch NeurPsych. 1939;42(1):187-188. doi:10.1001/archneurpsyc.1939.02270190195019

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In addition to the regular administration of phenobarbital and potassium borotartrate, 35 epileptic patients received treatment three times a week with the following: an intravenous injection of 20 cc. of a 10 per cent solution of sodium chloride and 10 per cent sodium bromide and drop enemas consisting of 15 per cent magnesium sulfate and 10 per cent sodium bromide. Twelve patients with status epilepticus were given from 20 to 40 cc. of the hypertonic solution. Approximately two thirds of the patients showed some improvement either in seizures or in behavior. Seven patients having an attack of migraine received intravenous injections. All were relieved of the existing headache, and some subsequently had headaches more rarely. Scattered observations were also made of the effect of the injection on the pressure of the cerebrospinal fluid, the pH of the urine and the concentration of the blood. Various theories and observations dealing

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