It has been suggested that convulsions in epilepsy1 and during insulin hypoglycemia2 may be influenced by varying body hydration. It has therefore been inferred that the disturbances in the distribution of water in the brain may be responsible for the convulsive phenomena. The present widespread employment of convulsant doses of insulin in the treatment of psychotic disorders has made timely the experimental investigation of the distribution of water in the brain following the administration of insulin. The purpose of the present communication is to present the results of the chemical analyses of the brains from normal cats and those given injections of insulin from which, by appropriate calculations, the distribution of water and electrolytes could be estimated. We have also included the results of the analyses of muscle from these animals, since this tissue represents the largest depot of water in the body.
PROCEDURE AND METHODS
YANNET H. EFFECT OF PROLONGED INSULIN HYPOGLYCEMIA ON DISTRIBUTION OF WATER AND ELECTROLYTES IN BRAIN AND IN MUSCLE. Arch NeurPsych. 1939;42(2):237–247. doi:10.1001/archneurpsyc.1939.02270200057006
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