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August 1939

LIPOIDS AND PROTEINS IN FLUID OBTAINED FROM APPROXIMATELY COMPLETE DRAINAGE OF THE CEREBROSPINAL SYSTEM

Author Affiliations

NEW HAVEN, CONN.

From the Department of Psychiatry and Mental Hygiene, Yale University School of Medicine.

Arch NeurPsych. 1939;42(2):260-272. doi:10.1001/archneurpsyc.1939.02270200080008
Abstract

There is considerable uncertainty with regard to the amounts, if any, of cholesterol and fatty acids in the spinal fluid, largely because the methods available are not sufficiently refined to measure accurately the small quantities in a few cubic centimeters of fluid. The large amounts (80 to 120 cc.) of cerebrospinal fluid removed in preparing patients for encephalographic examination have made it possible to obtain sufficient lipoid material for study. The proteins were determined by several methods in order to obtain data on the ratio between cholesterol and protein in spinal fluid. These results proved interesting in connection with previous studies on composition and formation of transudates.1

The early attempts of Mott2 and of Mestrezat3 to recover cholesterol from the cerebrospinal fluid of persons free from obvious meningeal disorders yielded nothing, or only very slight traces. Subsequent workers have reported finding amounts that ranged from zero to

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