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August 1939

FATAL HYPOGLYCEMIA: A Clinicopathologic Study

Arch NeurPsych. 1939;42(2):286-297. doi:10.1001/archneurpsyc.1939.02270200106010

The use of insulin in the treatment of diabetes mellitus and its recent employment in the therapy of schizophrenia and other conditions carry the possibility of undesirable and dangerous complications, the one most feared being a state of coma from which recovery does not occur. The effects on the nervous system of hypoglycemic states of long standing are not completely understood, but the increasing number of studies along this line give evidence that definite progress is being made. We have had the opportunity to study a case with special methods which, it is hoped, will add to information relative to the pathologic picture.

SUMMARY OF THE LITERATURE  Olmsted and Logan1 reported on the possible connection between the lowering of blood sugar and anoxia of the brain. Kleitman and Magnus2 produced insulin convulsions in rabbits under conditions of artificial respiration and concluded that the convulsions were not secondary to