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November 1939

INVOLVEMENT OF THE NERVOUS SYSTEM ASSOCIATED WITH ENDOCARDITIS: NEUROPSYCHIATRIC AND NEUROPATHOLOGIC OBSERVATIONS IN FORTY-TWO CASES OF FATAL OUTCOME

Author Affiliations

ROCHESTER, MINN.

From the Section on Pathologic Anatomy (Dr. Kernohan), the Section on Neurology (Dr. Woltman) and the Division of Medicine (Dr. Barnes), of the Mayo Clinic.

Arch NeurPsych. 1939;42(5):789-809. doi:10.1001/archneurpsyc.1939.02270230011001
Abstract

The neurologic and psychiatric complications of endocarditis are rather well known, but awareness of the high incidence of neuropathologic changes and the effort to surmise their existence on clinical evidence seem to be lacking. The various types of endocarditis have been delineated, and it appears that they may be correlated with the various types of encephalic injury. Additional clinical observation will be necessary before it can be decided to what extent dominant neuropsychiatric traits may be similarly correlated.

NEUROPSYCHIATRIC DISORDERS ASSOCIATED WITH ACUTE ARTICULAR RHEUMATISM AND WITH CHOREA  It is well known that acute simple endocarditis, or rheumatic endocarditis, and acute articular rheumatism are closely related. Cerebral involvement with the latter disease was said in the middle of the nineteenth century to have occurred in about 4.8 per cent of cases and to have had almost always a fatal termination. If the acute articular rheumatism is otherwise uncomplicated, the association

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