In recent years attempts have been made to attribute to allergic mechanisms many diverse diseases of unknown pathogenesis. These attempts have occasionally led to sweeping conclusions—conclusions which do not appear to be warranted on the basis of the facts adduced.
Allergic phenomena have been mentioned in connection with a number of neurologic conditions, and it has been suggested that certain of these diseases may be entirely or partially based on allergy, e. g., convulsive states, optic neuritis, encephalopathies, migraine, palsies and multiple sclerosis.
In a few of these conditions there seems to be some clinical or laboratory evidence which justifies the assumption that in at least some cases the disease is associated with states of specific acquired hypersensitivity to foods, drugs, inhalants, or other environmental substances, or foreign serums. In others there is no such evidence, and the suspicion of a relationship is based merely on similarities observed between the
BAER RL, SULZBERGER MB. ROLE OF ALLERGY IN MULTIPLE SCLEROSISINCIDENCE OF ATOPY IN A SERIES OF FORTY CASES. Arch NeurPsych. 1939;42(5):837–841. doi:10.1001/archneurpsyc.1939.02270230059004