Total or partial absence of the corpus callosum, a developmental anomaly of rare occurrence,1 was until lately diagnosed only at autopsy. Its recognition during life was made possible by the development of pneumoencephalography. Five cases in which diagnosis was made by this method were presented by Hyndman and Penfield2 at a meeting of the American Neurological Association in June 1934. Independently, Davidoff and Dyke3 reported at the same meeting 3 similar cases.
Operative inspection of the lesion in the second case of Hyndman and Penfield2 and autopsy in the second case of Davidoff and Dyke3 gave a clue to the understanding of the pneumoencephalographic picture of agenesis of the corpus callosum. Hyndman and Penfield concluded that the following features are of primary importance in the diagnosis of this condition: (1) "symmetrical separation of the anterior horns, with a moniliform shadow of gas between them which
Kunicki A, Chorobski J. VENTRICULOGRAPHIC DIAGNOSIS OF AGENESIS OF THE CORPUS CALLOSUM. Arch NeurPsych. 1940;43(1):139–145. doi:10.1001/archneurpsyc.1940.02280010147011
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