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February 1940

EFFECTS OF ETHYL ALCOHOL ON THE CEREBRAL CORTEX AND THE HYPOTHALAMUS OF THE CAT

Author Affiliations

CHICAGO

From the Division of Psychiatry, Department of Medicine, and the Otho S. A. Sprague Memorial Institute, the University of Chicago.

Arch NeurPsych. 1940;43(2):334-340. doi:10.1001/archneurpsyc.1940.02280020142012
Abstract

It is our purpose in this communication to report a series of experiments designed to investigate the effects of alcohol on the cerebral cortex and the hypothalamus of the cat, and to discuss briefly the significance of the results with regard to the functional interrelationships of these two portions of the central nervous system.

METHODS  The methods of physiologic and pharmacologic investigation developed in this laboratory have been described in previous reports;1 as employed in the present study, they were as follows:

Acute Preparations (20 experiments).  —The cat was anesthetized lightly with ether or pentobarbital sodium and prepared for kymographic recording of the respiration and blood pressure. By means of the Horsley-Clarke stereotaxic technic, insulated needle electrodes were then inserted into selected regions of the hypothalamus and cerebral cortex, rendering possible observation of the effects of stimulating these structures before and after various solutions of alcohol were injected directly

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