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April 1940

INFLUENCE OF INSULIN AND OF STIMULATION OF THE SYMPATHETIC NERVOUS SYSTEM ON THE BLOOD: STUDY OF THE SUGAR CONTENT, CARBON DIOXIDE TENSION AND pH

Arch NeurPsych. 1940;43(4):726-735. doi:10.1001/archneurpsyc.1940.02280040113007
Abstract

In a number of investigations, it has been shown by Gellhorn and his collaborators1 that anoxia and hypoglycemia affect the central nervous system in a similar manner and bring about potentiating effects on this system if the two procedures are combined. It was concluded that both anoxia and hypoglycemia decrease the oxidative state in the brain and that this, in turn, leads to stimulation of the sympathetic centers.

Himwich and his associates2 recently called attention to effects on the vagus nerve during insulin hypoglycemia and anoxia, and concluded from these observations that the major effect of insulin hypoglycemia is increased parasympathetic activity. For this reason, it seemed to us of interest to find additional criteria for the nature of the effects produced by insulin hypoglycemia.

It is well known that in conditions of excitement, in addition to signs of general increased activity and discharge of epinephrine (increased heart

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