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April 1940

EFFECT OF INSULIN SHOCK ON THE HEART AND BLOOD PRESSURE IN TREATMENT OF SCHIZOPHRENIA

Arch NeurPsych. 1940;43(4):784-791. doi:10.1001/archneurpsyc.1940.02280040171011
Abstract

Insulin shock treatment has become a widely used method of combating schizophrenia. As many favorable results of this therapy have been reported, it was decided to follow the effect of the treatment on the size of the heart by measurement of the cardiac shadow in routine roentgenograms taken at a distance of 7 feet (213.4 cm.) at intervals during the course and after cessation of the treatment. Whenever possible, daily determinations of blood pressure were also made. It is our purpose in this paper to present a summary of our findings, giving attention particularly to changes in the size of the cardiac shadow and, second, to changes in blood pressure.

Six regularly committed schizophrenic patients at the Metropolitan State Hospital were selected for insulin shock therapy. All the patients showed the cardinal symptoms of dementia praecox: hallucinations; loosely knit, unsystematized delusions; incoherence; irrelevancy; blocking; mannerisms; seclusiveness; intrapsychic ataxia; lack of

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