In 1930, Gardner and Frazier1 reported a family in which von Recklinghausen's disease, in the form of bilateral tumors of the acoustic nerve, had been transmitted as a dominant mendelian trait through five generations. At the time of the original report, 38 of the 217 members of the family were affected. Necropsy was performed on 2 members of the family and revealed bilateral acoustic neurofibromas. After the publication of the first report, symptoms of a tumor of the spinal cord developed in 1 of the affected members. This tumor was removed and likewise proved to be a neurofibroma; the case was subsequently reported by Gardner.2
The present report, the third concerning this family, deals chiefly with the pathologic material obtained from 4 members since the last publication.3 One of these members (case 4) represents the only case thus far observed in which the disease has been recognized
GARDNER WJ, TURNER O. BILATERAL ACOUSTIC NEUROFIBROMAS: FURTHER CLINICAL AND PATHOLOGIC DATA ON HEREDITARY DEAFNESS AND RECKLINGHAUSEN'S DISEASE. Arch NeurPsych. 1940;44(1):76–99. doi:10.1001/archneurpsyc.1940.02280070084004
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