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This volume contains fifteen articles, all dealing with problems pertaining to schizophrenia. The authors emphasize that as schizophrenia is not an anatomic disease and has been studied mainly by psychologic methods, the application of the physiologic principles of the school of Pavlov may be of value. Pavlov defined schizophrenia as a chronic hypnotic state, which involves both the cortical and the subcortical fields and serves as a protective inhibitory mechanism of "varied intensity and extensity." In schizophrenia the conditioned and nonconditioned reflexes are diminished, or are obtained with difficulty; they easily disappear and generally indicate lowered tonus of irritability of the cortex and the subcortex. There is a disturbance in balance between the irritability and the inhibition of the ganglion cells, the function of the cortical cells being on the whole markedly reduced.
A number of articles, on such subjects as platysmographic observations in cases of schizophrenia, the phytotoxic reaction
Pathophysiologic Problems and Treatment of Schizophrenia.. Arch NeurPsych. 1940;44(1):240–241. doi:10.1001/archneurpsyc.1940.02280070248019
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