Since the classic experiment of Wilson,1 it has been generally agreed that electrical stimulation of the corpus striatum gives no primary motor effects. At the same time, clinical evidence has accumulated2 which associates striatal dysfunction with impairment of motor activities originating elsewhere. The first adequate experimental proof of this relation was reported recently by Mettler, Ades, Lipman and Culler.3 These investigators resorted to simultaneous activation of cortical and striatal motor centers, observing that "stimulation of the caudate nucleus in the course of cortically initiated movement produced inhibition of the movement... best described as a melting away of the cortical effect." The purpose of the present communication is to report an essential confirmation and extension of the evidence on experimentally produced striatal inhibition.
EXPERIMENTAL PROCEDURE
In 10 cats the caudate nucleus (and in 1 the putamen and claustrum as well) was systematically stimulated by faradic current from bipolar