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April 1941

POLIOENCEPHALITIS HAEMORRHAGICA OF WERNICKE ASSOCIATED WITH FEBRILE DISEASEREPORT OF TWO CASES, ONE OCCURRING DURING TYPHOID FEVER AND VERIFIED BY AUTOPSY

Author Affiliations

SHANGHAI, CHINA

From the Division of Neuropsychiatry and the Department of Medicine, National Medical College of Shanghai.

Arch NeurPsych. 1941;45(4):658-665. doi:10.1001/archneurpsyc.1941.02280160090005
Abstract

After Wernicke's original publication1 in 1881, polioencephalitis haemorrhagica was long thought to be associated with chronic alcoholism.2 In recent years, however, many cases of the disease in nonalcoholic persons have been reported. Tanaka,3 in 1934, observed this condition in breast-fed infants and it was interpreted in Japan as the result of "human milk intoxication." In 1936 Uchimura and Akimoto4 reported a case associated with cerebral vascular syphilis. Környey5 recorded 2 cases in 1937. In 1 of them a Korsakoff psychosis developed after gastric resection for cancer, and in the other persistent vomiting accompanied recurrent carcinoma of the cervix uteri. In the same year Neubürger6 reported 3 cases of the disease associated with chronic gastritis. Polioencephalitis haemorrhagica had also been observed in cases of Hodgkin's disease (Környey7), subcutaneous and pulmonary abscesses and malaria (Neubürger8), scurvy (Alexander and Putnam9), nutritional deficiency (Ecker and Woltman

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