Dilantin sodium is being increasingly used in treatment of epilepsy because it appears to be effective in controlling seizures of the grand mal type in many of the patients who are not benefited by phenobarbital and bromides. The occurrence of hepatomegaly and splenomegaly in association with pyrexia, a severe scarlatiniform erythema and widespread dermatitis eventuating in dermatitis exfoliativa in a case in which a large amount of the drug had been taken warrants a report.
REPORT OF CASE
—Mrs. S. S., aged 34, white, was admitted to the Jewish Hospital on June 7, 1940, complaining of weakness, fever and a rash of four days' duration. Her family history was without significance; there had never been a case of epilepsy. Except for the usual sicknesses of childhood, she had never been ill. There had been 3 pregnancies. One child died of pneumonia, and 2 were alive and well.Epilepsy first
MANDELBAUM H, KANE LJ. DILANTIN SODIUM POISONINGREPORT OF A CASE WITH DERMATITIS EXFOLIATIVA, PYREXIA AND HEPATIC AND SPLENIC ENLARGEMENT. Arch NeurPsych. 1941;45(5):769–771. doi:10.1001/archneurpsyc.1941.02280170047003