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October 1941

ANTICONVULSIVE ACTION OF AZOSULFAMIDE IN PATIENTS WITH EPILEPSY

Arch NeurPsych. 1941;46(4):676-694. doi:10.1001/archneurpsyc.1941.02280220109008
Abstract

The purpose of this study was to continue the investigation of the effects of the anticonvulsive action of certain vital dyes. In 1937 Cobb, Cohen and Ney1 reported the anticonvulsive action of vital dyes in experimental animals and in patients with epilepsy. Neutral red was demonstrated to have anticonvulsive action in experimental animals and brilliant vital red in both experimental animals and patients with epilepsy. In subsequent reports2 the first use of disodium 4-sulfamidophenyl-2'-azo-7'-acetylamino- 1'-hydroxynaphthalene - 3',6' - disulfonate (azosulfamide) as an anticonvulsant with epileptic patients was described. This dye, under the name of prontosil S, had previously been reported3 to be useful in the treatment of infection. Our work has now been carried further, and it is the purpose of this paper to describe its effect on 10 patients with severe epilepsy.

Among the reasons for trying this particular dye on epileptic patients were the following:

1. It

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