It has been known for several years that deficiency of vitamin E in the diet is responsible for the production of certain changes in the muscular and neuromuscular systems of experimental animals. Conditions reported to have resulted from such a deficiency are as follows: muscular dystrophy in the rat, guinea pig, rabbit and dog1; myopathies, involving especially the nonstriated musculature, in the duck and turkey2; encephalomalacia, pareses and cerebellar disorders in the chick3; various paralyses in the suckling rat,4 and pareses in the adult rat, with involvement of the posterior columns, pyramidal tracts and anterior horn cells of the spinal cord.5 These disturbances can be prevented, and even relieved, by adding to the animal's diet the deficient vitamin or alpha tocopherol, an alcohol having the properties of vitamin E.6 This substances was first isolated from wheat germ oil, but can now be produced synthetically.
DeJONG RN. VITAMIN E AND ALPHA TOCOPHEROL THERAPY OF NEUROMUSCULAR AND MUSCULAR DISORDERS. Arch NeurPsych. 1941;46(6):1068–1075. doi:10.1001/archneurpsyc.1941.02280240123008
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