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January 1942


Author Affiliations


From the Section on Neuropathology (Dr. Kernohan) and the Section on Clinical Neurology (Dr. Woltman) of the Mayo Clinic.

Arch NeurPsych. 1942;47(1):132-140. doi:10.1001/archneurpsyc.1942.02290010142009

While deposits of amyloid may accumulate in quantities sufficient to interfere with the function of some organs, such as the kidneys and the liver, the nervous system remains singularly spared of such encroachment. The reason for this is not obvious. In any event, the damage caused by amyloid, wherever it appears, seems to be the result of compression or of arterial obliteration. A few cases have been reported in which the brain was invaded. It should be noted that corpora amylacea and amyloid are unrelated substances. Small amounts of amyloid have been described in the large vessels of the base of the brain and their branches.

Fischer and Holfelder1 reported the case of a man aged 45 who in 1921 had been given extensive irradiation for a squamous cell carcinoma situated in the right temporal area. This treatment having failed, the area was excised in 1923. In 1929 a

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