That heart disease may be of importance in the production of convulsive seizures has been known since the studies by Littré,1 in 1843. Examples of this association were cited by Kussmaul,2 Lemoine3 and Lépine,4 about 1890, and Gowers' monograph on epilepsy5 (1885) contains a chapter on this subject. More recently, particularly in the French literature, case reports have appeared under the caption of "cardiac epilepsy."6
In an attempt to determine whether rheumatic heart disease is of etiologic significance in the production of seizures, cases in which convulsive seizures and rheumatic heart disease were present in the same person were reviewed. Of 2,153 patients with rheumatic heart disease examined during the period from July 1, 1934 to April 1, 1941 in University Hospital, 29 had an associated diagnosis of convulsive disorder. No cases of convulsive disorder were included in this series in which there was
FOSTER DB. ASSOCIATION BETWEEN CONVULSIVE SEIZURES AND RHEUMATIC HEART DISEASE. Arch NeurPsych. 1942;47(2):254–264. doi:10.1001/archneurpsyc.1942.02290020070006
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