Despite the wide use of drugs in the treatment of Parkinson's syndrome, there is on the whole a lack of specific and objective data with regard to their effect on the two outstanding symptoms of the disease, namely, rigidity and tremor. The object of the present study was (1) to compare the effects of the drugs commonly used in management of the disease with those of a number of relatively new drugs and (2) to attempt better to understand the site of action of these drugs.
METHOD AND MATERIAL
Many pharmacologic observations were made on a number of patients with Parkinson's syndrome showing varying degrees of rigidity and tremor. Of these, 2 were finally selected as the most suitable subjects for intensive and prolonged study.The first patient (S. I.), a woman aged 25, exhibited moderately marked rigidity of the right arm and leg, with mild tremor of these parts.
LOMAN J, MYERSON PG, MYERSON A. EXPERIMENTAL PHARMACOLOGY OF POSTENCEPHALITIC PARKINSON'S DISEASE. Arch NeurPsych. 1942;47(3):399–412. doi:10.1001/archneurpsyc.1942.02290030057004
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