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May 1942

Epilepsy and Cerebral Localization. A Study of the Mechanism, Treatment and Prevention of Epilepoic Seizures.

Arch NeurPsych. 1942;47(5):875-877. doi:10.1001/archneurpsyc.1942.02290050177018

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This book has its roots in an observation of Hippocrates on crossed convulsive movements, in the studies on stimulative epilepsy of Fritsch and Hitzig and in the keen clinical studies of Hughlings Jackson and Charles Sherrington. It is dedicated to the last two investigators.

By studying the physiologic reactions of the brains of conscious patients exposed at operation, Penfield and his associates have answered questions which for centuries have been asked in vain. They have observed the appearance and the circulation of the brains of patients before and during convulsions; they have stimulated various areas of the cortex, recorded the responses and correlated these with the patient's spontaneous seizures. The reports teach a great deal about the anatomic significance of the constituent manifestations of seizures and about the physiology of the brain of epileptic, and perhaps of normal, persons. Equally valuable are the authors' painstaking histologic studies on brain injuries,