In 1935 one of us (C. A. E.) and associates1 described a new procedure for examination of the olfactory sense by the blast injection and stream injection of odorous substances into the nasal passages. The method of blast injection was based on a new principle. We found in normal subjects, by the introduction of odorous substances into the nasal passages during periods of voluntary cessation of breathing, in known volume and under a known pressure, that a certain volume and pressure were necessary for the recognition and identification of the odor. The minimum volume required for the identification of the odor was called the minimum identifiable odor of the odorous substance. Furthermore, we found that the stream injection of an odorous substance for a fixed period produced olfactory fatigue—inability to identify the odor when injected into the nasal passage by blast injection—from which normal subjects recovered within a definite
ELSBERG CA, SPOTNITZ H. VALUE OF QUANTITATIVE OLFACTORY TESTS FOR LOCALIZATION OF SUPRATENTORIAL DISEASE: ANALYSIS OF ONE THOUSAND CASES. Arch NeurPsych. 1942;48(1):1–12. doi:10.1001/archneurpsyc.1942.02290070011001
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