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October 1942

DISTRIBUTION OF ALKALINE PHOSPHATASE IN NORMAL AND IN NEOPLASTIC TISSUES OF THE NERVOUS SYSTEM: A HISTOCHEMICAL STUDY

Author Affiliations

NEW YORK

From the Departments of Neurology and Neuropathology, Columbia University College of Physicians and Surgeons, and the Neurological Institute of New York.

Arch NeurPsych. 1942;48(4):518-530. doi:10.1001/archneurpsyc.1942.02290100018002
Abstract

The histochemical method for demonstration of alkaline phosphatase introduced by Gomori1 and by Takamatsu2 has made possible the precise location of this enzyme in tissues and in individual cells in which it had not previously been found. Thus, phosphatase has been shown to occur in the epithelium of the small intestine, the proximal convoluted tubules of the kidney, ossifying cartilage, embryonic perichondrium, capillary endothelium and certain tumors, notably osteogenic sarcomas in the chicken and mouse and a fibroadenoma of the breast in man3. The information obtained has provided support for the hypothesis of Lundsgaard4 that a phosphorylase-phosphatase system is important in the absorption of dextrose by the epithelium of the small intestine and in the reabsorption of dextrose in the proximal convoluted tubules of the kidney.5 The question of the function of phosphatase in the other tissue cells has become of considerable significance.

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