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November 1942

INSULIN SENSITIVITY OF PATIENTS WITH MENTAL DISEASE: FACTORS IN THEIR SERUM AFFECTING ACTION OF INSULIN

Author Affiliations

NEW YORK

From the Department of Internal Medicine of the New York State Psychiatric Institute and Hospital.

Arch NeurPsych. 1942;48(5):761-773. doi:10.1001/archneurpsyc.1942.02290110081003
Abstract

Recent advances in endocrinology have disclosed that many factors enter into the regulation of carbohydrate metabolism in the animal organism. Not only the pancreas and its secretion of insulin but the pituitary,1 the adrenals,2 the thyroid,3 the sex glands,4 the liver5 and the diet6 all play a role in the regulation of the metabolism of this dietary constituent. The part played by the various factors has been discussed in some previous publications7 and in a number of reviews on the subject.8

With the complexity of the problem in mind, a study of the insulin sensitivity of a group of patients with mental disease and of the possible presence of substances in their serum which affect the action of insulin is reported.

It has been known for some time that certain conditions render the blood sugar level susceptible to the effect of the

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