Since the introduction of convulsive shock therapy, various methods have been used to prevent the traumatic complications. Recently Yaskin1 described favorable results in preventing these complications by the use of magnesium sulfate as a curare-like agent. He injected intravenously 25 to 30 cc. of a 25 per cent sterile aqueous solution of magnesium sulfate as rapidly as possible. The injection was followed immediately by cutaneous flushing, with a concomitant subjective complaint of a marked sensation of "heat," heaviness of the eyelids, bilateral ptosis, weakness of the neck muscles, slurred speech and weakness of the extremities. This syndrome was produced in one to three minutes, and at the height of the reaction metrazol was injected, with a resulting "softened" convulsion. The peripheral muscular paresis usually disappeared within three to six minutes after the effect was reached. Yaskin reported on 256 magnesium sulfate-metrazol treatments administered to 23 patients, ranging in age
ROSENBAUM M, LIPTON SD. FATALITY FOLLOWING INTRAVENOUS ADMINISTRATION OF MAGNESIUM SULFATE: REPORT OF A CASE. Arch NeurPsych. 1942;48(5):818–822. doi:https://doi.org/10.1001/archneurpsyc.1942.02290110138008
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