With regard to bromide intoxication, opinion is divided as to the relative importance of the direct toxic effects of bromides, on the one hand, and the individual susceptibility and predisposing pathologic conditions, on the other. A recent experimental investigation by Jellinek, Angyal, Cohen and Miller,1 at the laboratory of applied physiology at Yale University, is of particular interest to this controversy. In that experiment 78 normal subjects received bromides orally for a period of four weeks in high enough doses to produce bromide levels in the blood serum of about 150 mg. per hundred cubic centimeters by the end of the medication period. The outstanding result of this experiment was the paucity of neurologic and psychiatric changes in the subjects when the bromide level in the blood reached values which by many authors have been stated to approach, or even to be within, the toxic zone.
The setting of
ANGYAL A. PREDISPOSING FACTORS IN BROMIDE INTOXICATION. Arch NeurPsych. 1943;49(3):359–382. doi:10.1001/archneurpsyc.1943.02290150047002
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