Since Ollivier's1 publication in 1837, primary sarcomatosis of the meninges, a diffuse infiltration of the cerebral and spinal leptomeninges by a tissue chiefly cellular and of sarcomatous appearance, has been known. Many observations confirming the existence of such a process were published. Then every diffuse neoplastic process in the leptomeninges, apparently primary, was believed to be "sarcomatosis of the meninges."
Leusden,2 in 1898, reported a case of a. similar lesion of the leptomeninges, microscopic examination of which showed round cells which looked like "sarcomatous cells" but were associated with bundles of fibers. Not daring to deny the idea of primary sarcomatosis, Leusden, nevertheless, suggested a possible gliomatous participation, and even origin, and designated the diffuse meningeal tumor in his case by the name of gliosarcoma.
Gradually, however, the importance of the concept of "sarcomatosis" diminished. The invasive potentialities of the intracranial glioma were increasingly taken into account. It
AMYOT R. MENINGEAL GLIOMATOSIS SECONDARY TO INTRAMEDULLARY GLIOMA. Arch NeurPsych. 1943;49(3):383–397. doi:10.1001/archneurpsyc.1943.02290150071003
Customize your JAMA Network experience by selecting one or more topics from the list below.