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June 1943

MYASTHENIA GRAVIS: Familial Occurrence

Author Affiliations

New York

From the Department of Neurology, Columbia University College of Physicians and Surgeons, and the Neurological Institute of New York.

Arch NeurPsych. 1943;49(6):904-908. doi:10.1001/archneurpsyc.1943.02290180128013

The recording of these 2 cases calls attention to the possibility that myasthenia gravis may have a familial tendency. Reference to some of the standard textbooks on neurology discloses a difference of opinion as to a multiple familial occurrence. "Myasthenia gravis occasionally appears in more than one member of the family." (Bing1); "There is never any familial or hereditary tendency in myasthenia gravis." (Ford2); "Heredity does not play any considerable role in spite of rare observations by Peter and Marina." (Curschmann3); "The disease is not familial or hereditary, but it appears to have a relationship to disease of the thyroid and the thymus glands, which have a tendency to run in families." (McCarthy4); "Heredo-familial tendencies are unknown save for the cases of Marinesco and Hart." (Wilson5); "The occasional presence of some heredo-degenerative stigmata naturally points to a congenital predisposition." (Wechsler6); "No case is on

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