The age and rate of growth of primary tumors arising from the meninges can seldom, if ever, be accurately determined. To judge the approximate age of neoplasms in other parts of the body, one usually depends on the duration of symptoms produced. Unfortunately, this criterion cannot be applied to intracranial tumors, particularly meningiomas. A lesion arising in the epileptogenic zone may manifest its presence early, whereas one involving a "silent area" of the brain may grow for a long time, often reaching an enormous size before its presence is suspected.
The age of secondary, or recurrent, tumors, on the other hand, can be accurately determined when the onset of growth, i. e., the time of the first operation, is known. The rate of growth of these recurrent lesions is variable and depends on the pathologic variety of the tumor, its location and the extent of the operative and postoperative treatment.
CLOWARD RB, KEPNER RD. MENINGIOMA OF THIRTY YEARS' DURATION: REPORT OF A CASE. Arch NeurPsych. 1943;50(3):327–334. doi:10.1001/archneurpsyc.1943.02290210105008
Customize your JAMA Network experience by selecting one or more topics from the list below.