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December 1943

CHEMOTHERAPY OF INTRACRANIAL INFECTIONS: II. CLINICAL AND PATHOLOGIC EFFECTS OF INTRACRANIAL INTRODUCTION OF SULFANILAMIDE, SULFATHIAZOLE AND SULFADIAZINE IN NORMAL DOGS

Author Affiliations

NASHVILLE, TENN.

From the Department of Surgery, Vanderbilt University School of Medicine.

Arch NeurPsych. 1943;50(6):633-651. doi:10.1001/archneurpsyc.1943.02290240017001
Abstract

In a previous paper,1 a preliminary report of early experiments was presented because it was felt that a high incidence of convulsions following the implantation of sulfathiazole on the cerebral cortex made immediate publication of that observation advisable.

In this report, additional data on the previously reported experiments and on a number of additional related experiments will be presented. One hundred and fifteen experiments on dogs form the basis of this paper. The study was designed to determine the clinical and pathologic effects of sulfanilamide, sulfathiazole and sulfadiazine on the brain and its coverings.2

METHODS AND RESULTS  All operative procedures were carried out with aseptic technic, and any indication of infection was investigated by means of cultures of the cerebrospinal fluid and of material from the wound and the brain obtained during life and at necropsy. Several experiments in which infections developed were not included.Such clinical factors

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