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Man in the skies faces complications and adjustments not known to man on earth. This small handbook is the gist of a series of lectures given in the School of Aviation Medicine at Pensacola, Fla. The material is embodied in nineteen chapters, eighteen tables and the same number of simple line figures. The book is a condensed statement of the physiology of the respiratory and the circulatory apparatus of man and the conditions which the body must meet and the compensations which it must make in order to function at high altitudes. The facts and data are simply and clearly stated. The book is essential for training of nonmedical personnel or as a thumbnail refresher course for physicians. It does not attempt to deal with the psychologic hazards of combat flight. Its usefulness would be enhanced by a list of references to more detailed presentations of the subjects discussed.