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January 1944


Arch NeurPsych. 1944;51(1):67-72. doi:10.1001/archneurpsyc.1944.02290250073005

The lethal effects of high body temperatures are well known; nevertheless, over brief periods the temperature may rise as high as 111 F., or even higher, with rapid and complete recovery. The period must be brief because at such high temperatures the pathologic alterations in the body cells rapidly become irreversible. The cells of the central nervous system are particularly susceptible to any prolonged nocive influence, such as anoxia, trauma, alcohol and bromide intoxication; hence it is not surprising to find that fever itself induces rapid and severe alterations. In this paper we shall point out that certain cells in the central nervous system are more liable to specific pathologic changes in that borderland of heat stroke between total death and total recovery. Numerous cases of so-called neurotic sequels to heat stroke have been reported, but few in which the pathologic process was so strikingly indicated by clinical symptoms pointing