Despite the multitude of investigative activities, the question of the histopathology of schizophrenia has remained controversial to date. Perhaps one of the factors contributing to this situation may reside in the well known difficulties associated with the procurement of case material from which valid conclusions can be drawn.
Accessibility to a comparatively large amount of case material, free of complicating factors, such as old age, chronic intercurrent disease, and changes in the brain before, during or after death, would therefore afford one the unique opportunity to contribute to the clarification of the problem. Material selected under such advantageous conditions was found in specimens from the brains of schizophrenic patients obtained for biopsy during prefrontal lobotomy. The patients could be freely chosen for that procedure with regard to age and health. Moreover, the patients were not physically ill at the time the specimens were taken, and a minimum of time elapsed
KIRSCHBAUM WR, HEILBRUNN G. BIOPSIES OF THE BRAIN OF SCHIZOPHRENIC PATIENTS AND EXPERIMENTAL ANIMALS. Arch NeurPsych. 1944;51(2):155–162. doi:10.1001/archneurpsyc.1944.02290260045004
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