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February 1944

ACETYLCHOLINE TREATMENT OF SCHIZOPHRENIA

Arch NeurPsych. 1944;51(2):171-175. doi:10.1001/archneurpsyc.1944.02290260061006
Abstract

The chief purpose of this paper is to report on the striking amelioration of a patient's schizophrenic illness following the administration of acetylcholine. The circumstances of the remission, if only in 1 case, seem to deserve report since their drastic and near catastrophic nature may throw some light on the mechanism of remission, not only with acetylcholine but possibly with other forms of shock therapy. The paper is also concerned with the effects of treatment with acetylcholine on 10 other patients with schizophrenia.

NEUROPHYSIOLOGIC EFFECTS OF ACETYLCHOLINE  Acetylcholine has been shown to have a stimulating effect at the myoneural junction, the parasympathetic endings, the sympathetic and parasympathetic ganglia and the cerebral cortex.1 Intravenous injection of the drug in human beings is followed by convulsions associated with temporary cardiac arrest. In 8 epileptic patients Henderson and Wilson2 observed various individual responses, namely, nausea, vomiting, intestinal peristalsis, sweating, changes in

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