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July 1944

ABOLITION OF BULBOCAPNINE CATALEPSY IN THE CAT BY AC-TETRAHYDRO-B-NAPHTHYLAMINE

Author Affiliations

SYKESVILLE, MD.

Arch NeurPsych. 1944;52(1):61-64. doi:10.1001/archneurpsyc.1944.02290310067007
Abstract

The production of a state of catalepsy in the cat by the use of bulbocapnine was first described by Peters1 in 1904. Much has been written subsequently regarding the manifestations of this drug in the experimental animal. Interest in this reaction is based on the resemblance of the experimentally induced cataleptic state to catatonic stupor in man.

This paper is principally concerned with the methods that have been reported to abolish or alter catalepsy produced by bulbocapnine. Only a few such agents have been described. Buchman and Richter2 showed that cocaine eliminates the experimental catatonia at once and that the animals do not return to the former stuporous state. Furthermore, if cocaine is injected before the bulbocapnine, it prevents the appearance of the catatonic syndrome.

Paterson and Richter3 studied the effects of carbon dioxide inhalations and of scopolamine on bulbocapnine catalepsy. They reported that the effects of

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