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January 1945

The Management of Neurosyphilis.

Arch NeurPsych. 1945;53(1):90. doi:10.1001/archneurpsyc.1945.02300010100014

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Dattner's book comes at the beginning of a new era, the penicillin era, in the treatment of neurosyphilis. While this particular drug is still in its infancy, Dattner can look back on two decades or more during which the treatment of neurosyphilis has been revolutionized by the introduction of malaria and pentavalent arsenicals. He consequently gives a scholarly presentation of what has been accomplished between the two world wars in a battle against the disease with which he has been closely identified.

The author brings a freshness of view to the subject. Instead of dealing with the clinical symptomatology and differential diagnosis of neurosyphilis, he relies for both diagnosis and prognosis, and even for therapeutic control, on examination of the spinal fluid. Instead of describing the time-honored intravenous and intrathecal treatments, he jumps right into a discussion of malaria therapy, insisting that as soon as the diagnosis is made the