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March 1946

Experimental Catatonia. A General Reaction-Form of the Central Nervous System and Its Implications for Human Pathology.

Arch NeurPsych. 1946;55(3):297-298. doi:10.1001/archneurpsyc.1946.02300140128010

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Since the discovery by the author in the 1920's that bulbocapnine was capable of reproducing the motor phenomena seen in catatonia, de Jong has pursued his researches with a number of collaborators and in various localities. The present work is an extension of the investigations published with Baruk (Rev. neurol. 2:532, 1929). De Jong has found that, far from being a specific effect of bulbocapnine, catatonia is a general reaction form attributable to disturbances of function of the central nervous system and that it may be produced by a wide variety of chemical and physical methods. Many drugs have been tested under varying circumstances, and the author has shown that in many instances, in the twilight zone between life and death produced by the administration of slightly sublethal doses, the animal responds with catatonia. It may be significant that a still higher dose provokes convulsive seizures, sometimes eventuating in

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