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October 1946

CLEIDOCRANIAL DYSOSTOSIS WITH PSYCHOSIS

Author Affiliations

DURHAM, N. C.

Arch NeurPsych. 1946;56(4):401-416. doi:10.1001/archneurpsyc.1946.02300210045003
Abstract

THERE was recently admitted to and treated at Duke Hospital a patient with cleidocranial dysostosis and a psychosis. The case was of especial interest because of the concatenation of the rare anatomic anomaly and schizophrenia. Particularly noteworthy in this case was the absence of psychotic manifestations in the patient's father, who possessed essentially the same physical defects to an even greater degree. The rarity of cleidocranial dysostosis, the constancy of the physical manifestations of the syndrome and the autosomal mendelian dominant mode of inheritance of the trait in at least the majority of instances1 make it worth while to redescribe this condition and to report an additional case even if it were not for the unusual psychiatric implications.

Cleidocranial dysostosis is a rare syndrome, affecting persons of both sexes and of all ages, and occurs in diverse racial and national groups. In 1760 Meckel2 reported the case of

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