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November 1946

Experimental Hypertension.

Arch NeurPsych. 1946;56(5):607. doi:10.1001/archneurpsyc.1946.02300220120011

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The collection of papers gathered into this volume indicates that an understanding of the mechanism of experimental renal hypertension is in the stage of apparently conflicting evidence and opposing views. The papers are those presented in February 1945 at a conference held by the Section of Biology, New York Academy of Sciences, on experimental hypertension and deal for the most part with the so-called renal hypertension experimentally produced. They make little attempt to correlate the evidence but offer the data and opinions of investigators who have explored various phases of the problem.

The renin-angiotonin system—its production and chemistry and the characteristics of its activity—is discussed, but "no conclusive proof [is] offered that it is in fact the cause of... elevated blood pressure." Dr. Irvine H. Page presents important support of the humoral pressor theory in demonstrating, on ear vessels of the perfused rabbit, a vasoconstrictor substance differing from angiotonin and