IN STUDIES of the effects of anoxia, hypoglycemia and alcohol on the normal electroencephalogram and the correlation of these changes with the degree of reduction of consciousness, we emphasized the fact that the degree of change in frequency in the electroencephalographic record may be of more importance than the appearance of any particular wave frequency.1 Thus several subjects experiencing comparable reduction in consciousness when exposed on different occasions to anoxia, hypoglycemia and alcohol all showed the same degree of slowing in the electroencephalogram, although the final mean frequency varied widely among the different subjects, depending on the initial mean frequency. With the rather mild disturbance in consciousness induced in these experiments, abnormally slow waves (7 per second or less) appeared only in those instances in which the control records were in the slow normal range. In contrast, the subject with an abnormally fast record (mean frequency, 12.87 cycles per
ENGEL GL, ROMANO J, GOLDMAN L. DELIRIUM: IV. Quantitative Electroencephalographic Study of a Case of Acute Arsenical Encephalopathy. Arch NeurPsych. 1946;56(6):659–664. doi:https://doi.org/10.1001/archneurpsyc.1946.02300230053005
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