IN A previous paper,1 a survey of the literature dealing with blood bromides in mental diseases was presented. Several investigators2 have made blood bromide studies of patients with manic-depressive psychosis. Zondek and Bier,2a in 1931, reported that in 29 out of 34 cases of manic-depressive psychosis studied the blood bromine content was from 40 to 60 per cent below the normal value (1 mg. per hundred cubic centimeters) established by them. These investigators obtained an average value of 0.572 mg. per hundred cubic centimeters for the 34 cases but did not state whether the patients were in the manic or in the depressed stage. Sacristán and Peraita2b analyzed the blood of 13 women classified as manic, hypomanic or melancholic and obtained bromine values ranging from 0.161 to 0.684 mg. per hundred cubic centimeters, with an average value of 0.423 mg. All these values were lower than
WIKOFF HL, MARVIN T, MARTIN RL. BROMINE CONTENT OF THE BLOOD IN MENTAL DISEASES: II. Manic-Depressive Psychosis. Arch NeurPsych. 1946;56(6):673–676. doi:10.1001/archneurpsyc.1946.02300230067007
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