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January 1947

EFFECTS OF PITRESSIN HYDRATION ON THE ELECTROENCEPHALOGRAMParoxysmal Slow Activity in Nonepileptic Patients with Previous Drug Addiction

Author Affiliations

Surgeon (R), United States Public Health Service LEXINGTON, KY.

From the United States Public Health Service Hospital.

Arch NeurPsych. 1947;57(1):78-83. doi:10.1001/archneurpsyc.1947.02300240094005

ALTHOUGH hydration by forcing of fluids and the use of pitressin has long been employed to precipitate epileptic seizures for diagnostic purposes in persons suspected of having idiopathic epilepsy,1 no study has been made of the electroencephalographic changes produced by this procedure, either in normal or in epileptic subjects. A single injection of pitressin has been reported to have no effect on the electroencephalogram,2 but no data have been found on the effects of water intoxication except for the statement by Allen3 that some experiments of this type on dogs had been attempted.

The present study was undertaken in an attempt to solve a clinical problem. A patient at the United States Public Health Service Hospital was referred for electroencephalographic study because he exhibited periodic episodes of antisocial behavior. A diagnosis of psychopathic personality had been made, but it was desired to rule out epilepsy. A routine