BECAUSE of the dearth of knowledge concerning metabolic changes caused by poliomyelitic infection of the central nervous system, it appeared of interest to study possible electrophysiologic alterations of the brain during the course of the disease. Electroencephalograms were therefore taken of rhesus monkeys and of guinea pigs with experimental infection with simian or murine virus. In addition, 17 persons with postpoliomyelitic paralyses were studied.1
Five monkeys were given intracerebral injections of simian virus into the right frontal area: Three received the RMV strain (0.5 cc. of viral cord suspension [1: 10 or 1: 100]); and 2, the Aycock strain (0.5 cc. of a 1:50 suspension). Two additional monkeys served as controls: One was given an intracerebral injection of 0.5 cc. of a 10 per cent Aycock cord suspension inactivated by boiling for twenty minutes, and the other received 0.5 cc. of isotonic solution of sodium chloride. Ten guinea pigs
PACELLA BL, JUNGEBLUT CW, KOPELOFF N, KOPELOFF LM. THE ELECTROENCEPHALOGRAM IN POLIOMYELITIS. Arch NeurPsych. 1947;58(4):447–451. doi:10.1001/archneurpsyc.1947.02300330059005
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